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Paper · 1812.10366 · 2018

A Poisson-Gaussian Denoising Dataset with Real Fluorescence Microscopy Images

arXiv · PDF · Open in the Atlas

Code that ran

We lifted 22 functions out of this paper's own repositories and ran 14 of them in a sandbox. "Ran" means the function executed on a synthesized input and returned a value. It is not a reproduction of the paper's results.

RepositoryRoleRan
bmmi/denoising-fluorescence canonical 10 of 11
csm9493/FBI-Denoiser pwc_unofficial 3 of 10
yinhaoz/denoising-fluorescence pwc_unofficial 1 of 1
FunctionStatusWhere it lives
add_noise Ran bmmi/denoising-fluorescence/denoising/utils/noise.py
code served (permissive licence) · get_code("6f5ae543b2665234")
adjust_learning_rate Ran bmmi/denoising-fluorescence/denoising/utils/practices.py
code served (permissive licence) · get_code("14ebf34e2f003912")
annealing_cos Ran yinhaoz/denoising-fluorescence/denoising/utils/practices.py
code served (permissive licence) · get_code("ba05401cbaac305f")
annealing_linear Ran bmmi/denoising-fluorescence/denoising/utils/practices.py
code served (permissive licence) · get_code("6ea5c4823811a3e0")
cal_psnr Ran bmmi/denoising-fluorescence/denoising/utils/metrics.py
code served (permissive licence) · get_code("08df5d271f487b61")
conv1x1 Ran csm9493/FBI-Denoiser/core/unet.py
code served (permissive licence) · get_code("9200656a2a28834f")
conv3x3 Ran csm9493/FBI-Denoiser/core/unet.py
code served (permissive licence) · get_code("fe1bac001ffc64d5")
conv3x3 Ran bmmi/denoising-fluorescence/denoising/models/unet.py
code served (permissive licence) · get_code("8d908c5ef8d3e11d")
fluore_to_tensor Ran bmmi/denoising-fluorescence/denoising/utils/data_loader.py
code served (permissive licence) · get_code("2190c9625267f12c")
is_image_file Ran bmmi/denoising-fluorescence/denoising/utils/data_loader.py
code served (permissive licence) · get_code("3002f15097305815")
module_size Ran bmmi/denoising-fluorescence/denoising/utils/misc.py
code served (permissive licence) · get_code("8d8b366633b88388")
stitch_pathes Ran bmmi/denoising-fluorescence/denoising/utils/misc.py
code served (permissive licence) · get_code("d7ed95b364fdca49")
to_numpy Ran bmmi/denoising-fluorescence/denoising/utils/misc.py
code served (permissive licence) · get_code("c6c52ec834adb730")
upconv2x2 Ran csm9493/FBI-Denoiser/core/unet.py
code served (permissive licence) · get_code("87dc2e4625e5eb8c")
BlindSpotConv Not yet run csm9493/FBI-Denoiser/core/dbsn.py
code served (permissive licence) · get_code("0c73479d03c2508a")
estimated_bias Not yet run csm9493/FBI-Denoiser/core/loss_functions.py
code served (permissive licence) · get_code("a5d2dc2ed601363c")
get_PSNR Not yet run csm9493/FBI-Denoiser/core/utils.py
code served (permissive licence) · get_code("f44d660b6ccbeea9")
get_SSIM Not yet run csm9493/FBI-Denoiser/core/utils.py
code served (permissive licence) · get_code("d5f765357da5f38b")
im2patch Not yet run csm9493/FBI-Denoiser/core/utils.py
code served (permissive licence) · get_code("f42a21ac3a36dd53")
mse_affine Not yet run csm9493/FBI-Denoiser/core/loss_functions.py
code served (permissive licence) · get_code("2af64ac313fcf88e")
mse_bias Not yet run csm9493/FBI-Denoiser/core/loss_functions.py
code served (permissive licence) · get_code("ba6e70b8f2432f12")
pil_loader Not yet run bmmi/denoising-fluorescence/denoising/utils/data_loader.py
code served (permissive licence) · get_code("b38192a90bf3af95")

Repositories linked to this paper

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Abstract

Fluorescence microscopy has enabled a dramatic development in modern biology. Due to its inherently weak signal, fluorescence microscopy is not only much noisier than photography, but also presented with Poisson-Gaussian noise where Poisson noise, or shot noise, is the dominating noise source. To get clean fluorescence microscopy images, it is highly desirable to have effective denoising algorithms and datasets that are specifically designed to denoise fluorescence microscopy images. While such algorithms exist, no such datasets are available. In this paper, we fill this gap by constructing a dataset - the Fluorescence Microscopy Denoising (FMD) dataset - that is dedicated to Poisson-Gaussian denoising. The dataset consists of 12,000 real fluorescence microscopy images obtained with commercial confocal, two-photon, and wide-field microscopes and representative biological samples such as cells, zebrafish, and mouse brain tissues. We use image averaging to effectively obtain ground truth images and 60,000 noisy images with different noise levels. We use this dataset to benchmark 10 representative denoising algorithms and find that deep learning methods have the best performance. To our knowledge, this is the first real microscopy image dataset for Poisson-Gaussian denoising purposes and it could be an important tool for high-quality, real-time denoising applications in biomedical research.

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