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Paper · 1911.00081 · 2019

Scaling structural learning with NO-BEARS to infer causal transcriptome networks

arXiv · PDF · Open in the Atlas

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We lifted 1 functions out of this paper's own repositories and ran 1 of them in a sandbox. "Ran" means the function executed on a synthesized input and returned a value. It is not a reproduction of the paper's results.

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howchihlee/BNGPU canonical 1 of 1
FunctionStatusWhere it lives
W_reg_init Ran howchihlee/BNGPU/BNGPU/NOBEARS.py
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Abstract

Constructing gene regulatory networks is a critical step in revealing disease mechanisms from transcriptomic data. In this work, we present NO-BEARS, a novel algorithm for estimating gene regulatory networks. The NO-BEARS algorithm is built on the basis of the NOTEARS algorithm with two improvements. First, we propose a new constraint and its fast approximation to reduce the computational cost of the NO-TEARS algorithm. Next, we introduce a polynomial regression loss to handle non-linearity in gene expressions. Our implementation utilizes modern GPU computation that can decrease the time of hours-long CPU computation to seconds. Using synthetic data, we demonstrate improved performance, both in processing time and accuracy, on inferring gene regulatory networks from gene expression data.

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