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Paper · 2312.05063 · 2023

Individualizing Glioma Radiotherapy Planning by Optimization of Data and Physics-Informed Discrete Loss

arXiv · PDF · Open in the Atlas

Code that ran

We lifted 20 functions out of this paper's own repositories and ran 15 of them in a sandbox. "Ran" means the function executed on a synthesized input and returned a value. It is not a reproduction of the paper's results.

RepositoryRoleRan
m1balcerak/gliodil canonical 9 of 11
rayzhangzirui/pinn canonical 6 of 9
FunctionStatusWhere it lives
binarize Ran rayzhangzirui/pinn/losses.py
pointer only (licence: NONE) · get_code("ee7e0a67eca3ee28")
cache_to_file Ran m1balcerak/gliodil/code/plottools.py
code served (permissive licence) · get_code("4865176137f9d3d0")
copy_nested_dict Ran rayzhangzirui/pinn/options.py
pointer only (licence: NONE) · get_code("22f94f60d5586669")
double_logistic_sigmoid Ran rayzhangzirui/pinn/losses.py
pointer only (licence: NONE) · get_code("0135144bb0642474")
get_cycle Ran m1balcerak/gliodil/code/plottools.py
code served (permissive licence) · get_code("22ca2b7ed6666fbf")
get_nested_dict Ran rayzhangzirui/pinn/options.py
pointer only (licence: NONE) · get_code("632f11ec63858bb5")
get_path Ran m1balcerak/gliodil/code/multigrid_plot.py
code served (permissive licence) · get_code("b451328072062978")
get_shift_csr Ran m1balcerak/gliodil/code/multigrid.py
code served (permissive licence) · get_code("4700c4cd9cc30e8c")
get_sparse_eye Ran m1balcerak/gliodil/code/linsolver.py
code served (permissive licence) · get_code("1888ce5897017b71")
load_dict Ran m1balcerak/gliodil/code/cases/GliODIL/GliODIL.py
code served (permissive licence) · get_code("0995427e3bf0a2f9")
noncircular_shift Ran m1balcerak/gliodil/code/multigrid.py
code served (permissive licence) · get_code("b1c0776a3d738999")
noncircular_shift_np Ran m1balcerak/gliodil/code/multigrid.py
code served (permissive licence) · get_code("9a498cd8ed444154")
sigmoid_binarize Ran rayzhangzirui/pinn/losses.py
pointer only (licence: NONE) · get_code("88800cf2c6434e65")
solve Ran m1balcerak/gliodil/code/linsolver.py
code served (permissive licence) · get_code("c69526301d326901")
update_nested_dict Ran rayzhangzirui/pinn/options.py
pointer only (licence: NONE) · get_code("5de29038e4f08ca4")
adjust_ticks Not yet run m1balcerak/gliodil/code/plottools.py
code served (permissive licence) · get_code("c4a38850b2174d3d")
ic Not yet run rayzhangzirui/pinn/growth.py
pointer only (licence: NONE) · get_code("1743033aea92c3af")
output_transform Not yet run rayzhangzirui/pinn/growth.py
pointer only (licence: NONE) · get_code("088b2d8571862c36")
pde Not yet run rayzhangzirui/pinn/growth.py
pointer only (licence: NONE) · get_code("18e15e03bdf17038")
plot_grid_matrix Not yet run m1balcerak/gliodil/code/multigrid_plot.py
code served (permissive licence) · get_code("fc3a5440e91aa8b0")

Repositories linked to this paper

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Abstract

Brain tumor growth is unique to each glioma patient and extends beyond what is visible in imaging scans, infiltrating surrounding brain tissue. Understanding these hidden patient-specific progressions is essential for effective therapies. Current treatment plans for brain tumors, such as radiotherapy, typically involve delineating a uniform margin around the visible tumor on pre-treatment scans to target this invisible tumor growth. This "one size fits all" approach is derived from population studies and often fails to account for the nuances of individual patient conditions. We present the GliODIL framework, which infers the full spatial distribution of tumor cell concentration from available multi-modal imaging, leveraging a Fisher-Kolmogorov type physics model to describe tumor growth. This is achieved through the newly introduced method of Optimizing the Discrete Loss, where both data and physics-based constraints are softly assimilated into the solution. Our test dataset comprises 152 glioblastoma patients with pre-treatment imaging and post-treatment follow-ups for tumor recurrence monitoring. By blending data-driven techniques with physics-based constraints, GliODIL enhances recurrence prediction in radiotherapy planning, challenging traditional uniform margins and strict adherence to the Fisher-Kolmogorov partial differential equation model, which is adapted for complex cases.

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