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Paper · 2406.11799 · 2024

Mix-Domain Contrastive Learning for Unpaired H&E-to-IHC Stain Translation

arXiv · PDF · Open in the Atlas

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We lifted 7 functions out of this paper's own repositories and ran 3 of them in a sandbox. "Ran" means the function executed on a synthesized input and returned a value. It is not a reproduction of the paper's results.

RepositoryRoleRan
ssongwang/mix-domaincontrastivelearning canonical 3 of 7
FunctionStatusWhere it lives
get_filter Ran ssongwang/mix-domaincontrastivelearning/models/networks.py
pointer only (licence: NONE) · get_code("acc24402a2d089fa")
get_norm_layer Ran ssongwang/mix-domaincontrastivelearning/models/networks.py
pointer only (licence: NONE) · get_code("b27dffc0609fbec0")
get_pad_layer Ran ssongwang/mix-domaincontrastivelearning/models/networks.py
pointer only (licence: NONE) · get_code("50aa4a59fe718c61")
calculate_kid_given_paths Not yet run ssongwang/mix-domaincontrastivelearning/util/kid_score.py
pointer only (licence: NONE) · get_code("1d6a8004fcb7969c")
extract_lenet_features Not yet run ssongwang/mix-domaincontrastivelearning/util/kid_score.py
pointer only (licence: NONE) · get_code("52a83caf0655bb7d")
find_launcher_using_name Not yet run ssongwang/mix-domaincontrastivelearning/experiments/__main__.py
pointer only (licence: NONE) · get_code("0efffbfa7278dd55")
get_activations Not yet run ssongwang/mix-domaincontrastivelearning/util/kid_score.py
pointer only (licence: NONE) · get_code("7b41327814ab3634")

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Abstract

H&E-to-IHC stain translation techniques offer a promising solution for precise cancer diagnosis, especially in low-resource regions where there is a shortage of health professionals and limited access to expensive equipment. Considering the pixel-level misalignment of H&E-IHC image pairs, current research explores the pathological consistency between patches from the same positions of the image pair. However, most of them overemphasize the correspondence between domains or patches, overlooking the side information provided by the non-corresponding objects. In this paper, we propose a Mix-Domain Contrastive Learning (MDCL) method to leverage the supervision information in unpaired H&E-to-IHC stain translation. Specifically, the proposed MDCL method aggregates the inter-domain and intra-domain pathology information by estimating the correlation between the anchor patch and all the patches from the matching images, encouraging the network to learn additional contrastive knowledge from mixed domains. With the mix-domain pathology information aggregation, MDCL enhances the pathological consistency between the corresponding patches and the component discrepancy of the patches from the different positions of the generated IHC image. Extensive experiments on two H&E-to-IHC stain translation datasets, namely MIST and BCI, demonstrate that the proposed method achieves state-of-the-art performance across multiple metrics.

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