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Paper · 2411.02125 · NeurIPS · 2024

Revisiting K-mer Profile for Effective and Scalable Genome Representation Learning

Abdulkadir Çelikkanat, Andres Masegosa, Thomas Nielsen

arXiv · PDF · Open in the Atlas

Code that ran

We lifted 4 functions out of this paper's own repositories and ran 3 of them in a sandbox. "Ran" means the function executed on a synthesized input and returned a value. It is not a reproduction of the paper's results.

RepositoryRoleRan
abdcelikkanat/revisitingkmers canonical 3 of 4
FunctionStatusWhere it lives
NonLinearModel Ran abdcelikkanat/revisitingkmers/src/nonlinear.py
pointer only (licence: NONE) · get_code("c55d239688ccb919")
loss_func Ran abdcelikkanat/revisitingkmers/src/nonlinear.py
pointer only (licence: NONE) · get_code("b8415a5ca4e28ff0")
single_epoch Ran abdcelikkanat/revisitingkmers/src/nonlinear.py
pointer only (licence: NONE) · get_code("fdf60a19696b351b")
set_seed Not yet run abdcelikkanat/revisitingkmers/src/nonlinear.py
pointer only (licence: NONE) · get_code("6ac11eed8defa8ca")

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Abstract

Obtaining effective representations of DNA sequences is crucial for genome analysis. Metagenomic binning, for instance, relies on genome representations to cluster complex mixtures of DNA fragments from biological samples with the aim of determining their microbial compositions. In this paper, we revisit k-mer-based representations of genomes and provide a theoretical analysis of their use in representation learning. Based on the analysis, we propose a lightweight and scalable model for performing metagenomic binning at the genome read level, relying only on the k-mer compositions of the DNA fragments. We compare the model to recent genome foundation models and demonstrate that while the models are comparable in performance, the proposed model is significantly more effective in terms of scalability, a crucial aspect for performing metagenomic binning of real-world datasets.

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