CureAgent: A Training-Free Executor-Analyst Framework for Clinical Reasoning

Yixin Zhang, Tingting Xie

arXiv · PDF · Open in the Atlas

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• June01/CureAgent

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Abstract

Current clinical agent built on small LLMs, such as TxAgent suffer from a Context Utilization Failure, where models successfully retrieve biomedical evidence due to supervised finetuning but fail to ground their diagnosis in that information. In this work, we propose the Executor-Analyst Framework, a modular architecture that decouples the syntactic precision of tool execution from the semantic robustness of clinical reasoning. By orchestrating specialized TxAgents (Executors) with long-context foundation models (Analysts), we mitigate the reasoning deficits observed in monolithic models. Beyond simple modularity, we demonstrate that a Stratified Ensemble strategy significantly outperforms global pooling by preserving evidentiary diversity, effectively addressing the information bottleneck. Furthermore, our stress tests reveal critical scaling insights: (1) a Context-Performance Paradox, where extending reasoning contexts beyond 12k tokens introduces noise that degrades accuracy; and (2) the Curse of Dimensionality in action spaces, where expanding toolsets necessitates hierarchical retrieval strategies. Crucially, our approach underscores the potential of training-free architectural engineering, achieving state-of-the-art performance on CURE-Bench without the need for expensive end-to-end finetuning. This provides a scalable, agile foundation for the next generation of trustworthy AI-driven therapeutics. Code will be released on https://github.com/June01/CureAgent.

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